Statistically speaking, the most common cause of death for the international traveler while abroad is motor vehicle accidents, and second, is death from a pre-existing condition, such as heart disease, diabetes, or cancer. However, there are a number of other medical issues that can disrupt or ultimately ruin an international trip. With regard to the two top problems: drive carefully and defensively. If you are not comfortable behind the wheel, take other methods of transport or hire a driver. While these measures cannot insure accident avoidance, they can minimize the risk. Before traveling to a region where medical care may be difficult to obtain, have a thorough physical and make sure you are carrying a sufficient amount of any medications that you may be taking. Also remember that some conditions may not be detectable before you leave, so having good international insurance that will provide for treatment at the closest major medical facility and evacuation back to your home country is a wise decision.